Causes and Symptoms Banner

Iron deficiency anemia can affect

Iron deficiency anemia can affect both men and women, with women being more commonly affected. IDA is often underdiagnosed and undertreated because some people may not have any symptoms at first. Also, signs and symptoms of IDA can be similar to those of other conditions. That’s why it’s important to discuss any symptom you may experience with your doctor.

Iron deficiency anemia causes include

IDA can result from many different diseases or conditions, where your body is unable to circulate or store a healthy amount of iron:

Gastrointestinal conditions

Even if you have enough iron in your diet, your body may not be able to absorb it. This can happen if you have intestinal surgery (such as gastric bypass) or a disease of the intestine (such as Crohn's disease or celiac disease).

Cancer

Cancer-related anemia can develop due to many reasons, including chemotherapy, blood loss, lack of a certain hormone in people with kidney disease, and marrow involvement with tumor, among others.

Heart failure

People with chronic heart failure can suffer from gastrointestinal bleeding, inability to absorb enough iron, and inflammation which can lead to iron deficiency or IDA.

Women’s health conditions

In women, long or abnormal menstrual periods or bleeding fibroids in the uterus may cause low iron levels. Blood loss that occurs during childbirth is another cause of low iron levels in women.

Chronic kidney disease (CKD)

IDA is a prevalent complication of CKD, particularly in dialysis* patients, which can be due to impaired intestinal absorption of dietary iron, blood loss, chronic inflammation, and increased iron requirements during certain therapies.

Blood loss

Blood loss from internal bleeding, severe injuries, surgery, or frequent blood drawings could cause IDA.

*Please note: Injectafer should only be used when oral iron treatments haven't worked or if you have found that you are unable to tolerate the side effects related to oral iron treatment. It is also used to treat iron deficiency anemia in adults with chronic kidney disease who are not receiving dialysis.

Common iron deficiency anemia symptoms

Some IDA symptoms include

You may or may not experience symptoms with IDA. If you are experiencing any of these symptoms, please talk to your doctor. If you have questions about your condition, or if you want more information about IDA, talk to your doctor. Only your doctor can diagnose IDA.

Injectafer® (ferric carboxymaltose injection) is not indicated to treat the symptoms of IDA.

You may or may not experience symptoms with IDA. If you are experiencing any of these symptoms, please talk to your doctor. If you have questions about your condition, or if you want more information about IDA, talk to your doctor. Only your doctor can diagnose IDA.

Injectafer® (ferric carboxymaltose injection) is not indicated to treat the symptoms of IDA.

Doctor Discussion Guide

Information Discussion Awareness

Please talk to your doctor if you are experiencing any IDA symptoms. Make sure you’re asking a lot of questions! Download Your IDA Question Starter for your next appointment.

Download Now

The information on this website should not take the place of talking with your doctor or healthcare professional. If you have any questions about your condition, or if you want more information about iron deficiency anemia (IDA) or Injectafer, talk to your doctor. Only your doctor can decide if Injectafer is right for you.

Causes and Symptoms Page Navigation

Learn more about understanding your lab values

Important Safety Information

Injectafer® (ferric carboxymaltose injection) is available by prescription only. Ask your doctor or healthcare provider if Injectafer is right for you.

What is Injectafer?

Injectafer is a prescription iron replacement medicine administered only by or under the supervision of your healthcare provider. Injectafer is injected into your vein to treat iron deficiency anemia in adults. Injectafer should be used only if you have not responded well to treatment with oral iron, or if you are intolerant to oral iron treatment. It is also used to treat iron deficiency anemia in adults with chronic kidney disease who are not receiving dialysis.

It is not known if Injectafer is safe and effective for use in children.

IMPORTANT SAFETY INFORMATION

Who should not receive Injectafer?

You should not receive Injectafer if you are allergic to ferric carboxymaltose or any of the other ingredients in Injectafer. The active ingredient in Injectafer is ferric carboxymaltose, the inactive ingredients are: water for injection, sodium hydroxide and/or hydrochloric acid.

What should I tell my doctor or healthcare provider before receiving Injectafer?

Before you receive Injectafer, tell your healthcare provider about all of your medical conditions, including if you:

  • Have had an allergic reaction to iron given intravenously (into your vein), including Injectafer, or to other non-oral iron treatments
  • If you have, or have previously experienced, iron overload, or if your body has difficulty using iron appropriately
  • Have high blood pressure
  • Are pregnant or plan to become pregnant. It is not known if Injectafer will harm your unborn baby. Your healthcare provider will decide if it is safe for you to take Injectafer
  • Are breastfeeding or plan to breast feed. Injectafer passes into your breast milk. It is unknown whether Injectafer would pose a risk to your baby. Talk to your healthcare provider about the best way to feed your baby during treatment with Injectafer.

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Injectafer?

Injectafer can cause serious side effects, including:

  • Serious allergic reactions that may be life-threatening, including shock, low blood pressure, loss of consciousness, and death. Your doctor or healthcare provider will monitor you for signs and symptoms of an allergic reaction during and after each dose of Injectafer for at least 30 minutes. Other serious allergic reactions include itching, rash, hives, wheezing, or low blood pressure. You should report any signs and symptoms of an allergic reaction to Injectafer, in particular rashes, shortness of breath and wheezing to your doctor or healthcare provider.
  • High blood pressure, sometimes with facial flushing, dizziness, or nausea, has been seen during treatment with Injectafer. This increase in blood pressure typically resolves within 30 minutes. Your doctor or healthcare provider will monitor you for signs and symptoms of an increase in blood pressure following each use of Injectafer.

Other serious side effects that have been reported include rash, difficulty breathing, itching, rapid heartbeat, fever, chest discomfort, chills, swelling of the face, lips, or tongue, back pain, muscle aches, and fainting.

The most common side effects of Injectafer include:

  • Nausea, high blood pressure, flushing, low levels of phosphorous in your blood, dizziness, vomiting, headache, an increase in certain liver enzymes, and pain or bruising at the injection site. Potentially long-lasting brown staining of skin near the injection site may occur if Injectafer leaks out of the vein.

Excessive amounts of Injectafer may lead to a condition called iron overload, which is a buildup of iron and may be harmful.

These are not all of the possible side effects of Injectafer.

Tell your doctor if you have any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects.

General information about Injectafer

Injectafer may impact laboratory tests that measure iron in your blood for 24 hours after receiving Injectafer. Let your healthcare provider and laboratory staff know if you have received Injectafer within 24 hours of having blood tests.

To report side effects, contact American Regent at 1-800-734-9236 or E-mail: pv@luitpold.com or Fax: 1-610-650-0170.

You may also report side effects to the FDA at 1-800-332-1088 or www.fda.gov/medwatch.

The risk information provided here is not comprehensive. To learn more about Injectafer, talk with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at http://www.injectafer.com/pdf/pi.pdf or call 1-800-645-1706.

Please see Full Prescribing Information for Injectafer, including the bolded WARNING regarding hypersensitivity.